Purinethol Side Effects

Generic Name: Mercaptopurine

Please note - some side effects for Purinethol may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Purinethol - for the consumer

Purinethol

All medicines may cause side effects, but many people have no, or minor, side effects. No COMMON side effects have been reported with Purinethol . Seek medical attention right away if any of these SEVERE side effects occur when using Purinethol:

Severe allergic reactions (rash; itching; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dark urine; darkening of the skin; fever, chills, or sore throat; increased or painful urination; loss of appetite; nausea; pale stools; severe or persistent diarrhea; sores or white patches in the mouth; stomach pain, swelling, or tenderness; unusual bleeding or bruising; unusual growths or lumps; unusual tiredness or weakness; vomiting; yellowing of the skin or eyes.

For the professional

Purinethol

The principal and potentially serious toxic effects of Purinethol are bone marrow toxicity and hepatotoxicity.

Hematologic

The most frequent adverse reaction to Purinethol is myelosuppression. The induction of complete remission of acute lymphatic leukemia frequently is associated with marrow hypoplasia. Patients without TPMT enzyme activity (homozygous-deficient) are particularly susceptible to hematologic toxicity, and some patients with low or intermediate TPMT enzyme activity are more susceptible to hematologic toxicity than patients with normal TPMT activity, although the latter can also experience severe toxicity. Maintenance of remission generally involves multiple-drug regimens whose component agents cause myelosuppression. Anemia, leukopenia, and thrombocytopenia are frequently observed. Dosages and also schedules are adjusted to prevent life-threatening cytopenias.

Renal

Hyperuricemia and/or hyperuricosuria may occur in patients receiving Purinethol as a consequence of rapid cell lysis accompanying the antineoplastic effect. Renal adverse effects can be minimized by increased hydration, urine alkalinization, and the prophylactic administration of a xanthine oxidase inhibitor such as allopurinol. The dosage of Purinethol should be reduced to one third to one quarter of the usual dose if allopurinol is given concurrently.

Gastrointestinal

Intestinal ulceration has been reported. Nausea, vomiting, and anorexia are uncommon during initial administration, but may increase with continued administration. Mild diarrhea and sprue-like symptoms have been noted occasionally, but it is difficult at present to attribute these to the medication. Oral lesions are rarely seen, and when they occur they resemble thrush rather than antifolic ulcerations.

Miscellaneous

The administration of Purinethol has been associated with skin rashes and hyperpigmentation. Alopecia has been reported.

Drug fever has been very rarely reported with Purinethol. Before attributing fever to Purinethol, every attempt should be made to exclude more common causes of pyrexia, such as sepsis, in patients with acute leukemia.

Oligospermia has been reported.

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