Side Effects > Minocycline

Minocycline Side Effects

Brand Names: Dynacin, Solodyn, Minocin, Dynacin

Please note - some side effects for Minocycline may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

For the consumer Minocycline Minocycline Capsules Minocycline Extended-Release Tablets Minocycline Microspheres Minocycline Pellet-Filled Capsules For the professional Minocycline

Side Effects of Minocycline - for the consumer

Minocycline

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Minocycline:

Changes in skin color; diarrhea; difficulty swallowing; dizziness; feeling of a whirling motion; lightheadedness; loss of appetite; nausea; sensitivity to sunlight; unsteadiness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur when using Minocycline:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bleeding or discharge from the gums; bloody stools; blurred vision; decreased hearing; fever; headache; inflammation of the pancreas (stomach tenderness, nausea, vomiting, increased pulse rate); joint pain; muscle pain or weakness; pain, redness, or swelling in the mouth; painful sores in the mouth; redness or swelling of gums; red, swollen, blistered, or peeling skin; ringing in the ears; severe diarrhea; severe skin reaction to the sun; stomach cramps/pain; unusual tiredness or weakness; vaginal irritation or discharge.

Minocycline Capsules

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Minocycline Capsules:

Dizziness; drowsiness; lightheadedness; loss of appetite; nausea; stomach upset; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur when using Minocycline Capsules:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; blurred vision; bulging soft spots in infants; fever; headache; increased pressure in the head; inflammation of the pancreas (increased pulse, nausea, stomach tenderness, vomiting); joint pain, muscle pain or weakness; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe diarrhea; severe skin reaction to the sun; stomach pain/cramps; trouble swallowing; unusual tiredness or weakness; vaginal irritation or discharge; yellowing of the skin or eyes.

Minocycline Extended-Release Tablets

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Minocycline Extended-Release Tablets:

Dizziness; lightheadedness; mild headache or diarrhea; nausea; tiredness.

Seek medical attention right away if any of these SEVERE side effects occur when using Minocycline Extended-Release Tablets:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry, or bloody stool; blurred vision; change in amount of urine produced; changes in color of skin, teeth, or gums; dark urine; decreased hearing; fever; joint aches or pain; muscle pain or weakness; red, swollen, blistered, or peeling skin; severe or persistent headache, diarrhea, or tiredness; stomach cramps/pain; unusual bruising or bleeding; unusual tiredness or weakness; vaginal irritation or discharge; vision changes; yellowing of the eyes or skin.

Minocycline Microspheres

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Minocycline Microspheres:

Flu-like symptoms; headache; stomach upset.

Seek medical attention right away if any of these SEVERE side effects occur when using Minocycline Microspheres:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bleeding or discharge from the gums; fever; joint pain; muscle pain or weakness; painful sores in the mouth; red, swollen, or blistered skin; severe diarrhea; severe or persistent headache; stomach pain or cramps; unusual tiredness or weakness.

Minocycline Pellet-Filled Capsules

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Minocycline Pellet-Filled Capsules:

Diarrhea; dizziness; drowsiness; indigestion; lightheadedness; loss of appetite; nausea; sore mouth, throat, or tongue; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur when using Minocycline Pellet-Filled Capsules:

Severe allergic reactions (rash; hives; itching; difficulty swallowing or breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; blurred vision; change in the amount of urine produced; fever; hearing problems; inflammation of the pancreas (increased pulse, nausea, stomach tenderness, vomiting); joint pain; muscle pain or weakness; rectal or genital irritation; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe or persistent headache; severe skin reaction to the sun; severe, watery diarrhea; stomach pain or cramps; swollen glands; unusual bruising or bleeding; unusual tiredness or weakness; vaginal irritation or discharge; yellowing of the skin or eyes.

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For the professional

Minocycline

Due to oral Minocycline's virtually complete absorption, side effects to the lower bowel, particularly diarrhea, have been infrequent. The following adverse reactions have been observed in patients receiving tetracyclines.

Body as a whole:  Fever, and discoloration of secretions.

Gastrointestinal:  Anorexia, nausea, vomiting, diarrhea, dyspepsia, stomatitis, glossitis, dysphagia, enamel hypoplasia, enterocolitis, pseudomembranous colitis, pancreatitis, inflammatory lesions (with monilial overgrowth) in the oral and anogenital regions. Instances of esophagitis and esophageal ulcerations have been reported in patients taking the tetracycline-class antibiotics in capsule and tablet form. Most of these patients took the medication immediately before going to bed.

Genitourinary:  Vulvovaginitis.

Hepatic toxicity:  Hyperbilirubinemia, hepatic cholestasis, increases in liver enzymes, fatal hepatic failure, and jaundice. Hepatitis, including autoimmune hepatitis, and liver failure have been reported.

Skin:  Alopecia, erythema nodosum, hyperpigmentation of nails, pruritus, toxic epidermal necrolysis, and vasculitis. Maculopapular and erythematous rashes. Exfoliative dermatitis has been reported. Fixed drug eruptions have been reported. Lesions occurring on the glans penis have caused balanitis. Erythema multiforme and Stevens-Johnson syndrome have been reported. Photosensitivity is discussed above. Pigmentation of the skin and mucous membranes has been reported.

Respiratory:  Cough, dyspnea, bronchospasm, exacerbation of asthma, and pneumonitis.

Renal toxicity:  Interstitial nephritis. Elevations in BUN have been reported and are apparently dose related. Reversible acute renal failure has been reported.

Musculoskeletal:  Arthralgia, arthritis, bone discoloration, myalgia, joint stiffness, and joint swelling.

Hypersensitivity reactions:  Urticaria, angioneurotic edema, polyarthralgia, anaphylaxis/anaphylactoid reaction (including shock and fatalities), anaphylactoid purpura, myocarditis, pericarditis, exacerbation of systemic lupus erythematosus and pulmonary infiltrates with eosinophilia have been reported. A transient lupus-like syndrome and serum sickness-like reactions also have been reported.

Blood:  Agranulocytosis, hemolytic anemia, thrombocytopenia, leukopenia, neutropenia, pancytopenia, and eosinophilia have been reported.

Central Nervous System:  Convulsions, dizziness, hypesthesia, paresthesia, sedation, and vertigo. Bulging fontanels in infants and benign intracranial hypertension (pseudotumor cerebri) in adults have been reported. Headache has also been reported.

Other:  When given over prolonged periods, tetracyclines have been reported to produce brown-black microscopic discoloration of the thyroid gland. Cases of abnormal thyroid function have been reported.
 
Tooth discoloration in children less than 8 years of age and also, in adults has been reported.
 
Oral cavity discoloration (including tongue, lip, and gum) have been reported.
 
Tinnitus and decreased hearing have been reported in patients on Minocycline hydrochloride.
 
The following syndromes have been reported. In some cases involving these syndromes, death has been reported. As with other serious adverse reactions, if any of these syndromes are recognized, the drug should be discontinued immediately:
 
Hypersensitivity syndrome consisting of cutaneous reaction (such as rash or exfoliative dermatitis), eosinophilia, and one or more of the following: hepatitis, pneumonitis, nephritis, myocarditis, and pericarditis. Fever and lymphadenopathy may be present.
 
Lupus-like syndrome consisting of positive antinuclear antibody; arthralgia, arthritis, joint stiffness, or joint swelling; and one or more of the following: fever, myalgia, hepatitis, rash, and vasculitis.
 
Serum sickness-like syndrome consisting of fever; urticaria or rash; and arthralgia, arthritis, joint stiffness, or joint swelling. Eosinophilia may be present.

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