A-MethaPred Side Effects

Generic Name: Methylprednisolone

Please note - some side effects for A-MethaPred may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of A-MethaPred - for the consumer

A-methapred Solution

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using A-methapred Solution:

Acne; clumsiness; dizziness; facial flushing; feeling of whirling motion; general body discomfort; headache; increased appetite; increased sweating; nausea; nervousness; pain, swelling, or redness at the injection site; sleeplessness; upset stomach.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; changes in body fat; changes in menstrual periods; changes in skin color; chest pain; easy bruising or bleeding; mental or mood changes (eg, depression); muscle pain, weakness, or wasting; swelling of feet or legs; seizures; severe nausea or vomiting; sudden severe dizziness or headache; symptoms of infection (eg, fever, chills, sore throat); tendon or bone pain; thinning of the skin; unusual skin sensation; unusual weight gain; vision changes or other eye problems; vomit that looks like coffee grounds.

For the professional

A-Methapred

Fluid and Electrolyte Disturbances

1. Sodium retention

2. Fluid retention

3. Congestive heart failure in susceptible patients

4. Potassium loss

5. Hypokalemic alkalosis

6. Hypertension

Musculoskeletal

1. Muscle weakness

2. Steroid myopathy

3. Loss of muscle mass

4. Severe arthralgia

5. Vertebral compression fractures

6. Aseptic necrosis of femoral and humeral heads

7. Pathologic fracture of long bones

8. Osteoporosis

Gastrointestinal

1. Peptic ulcer with possible perforation and hemorrhage

2. Pancreatitis

3. Abdominal distention

4. Ulcerative esophagitis

Dermatologic

1. Impaired wound healing

2. Thin fragile skin

3. Petechiae and ecchymoses

4. Facial erythema

5. Increased sweating

6. May suppress reactions to skin tests

Neurological

1. Increased intracranial pressure with papilledema (pseudotumor cerebri) usually after treatment

2. Convulsions

3. Vertigo

4. Headache

Endocrine

1. Development of Cushingoid state

2. Suppression of growth in children

3. Secondary adrenocortical and pituitary unresponsiveness, particularly in times of stress as in trauma, surgery or illness

4. Menstrual irregularities

5. Decreased carbohydrate tolerance

6. Manifestations of latent diabetes mellitus

7. Increased requirements for insulin or oral hypoglycemic agents in diabetics

Ophthalmic

1. Posterior subcapsular cataracts

2. Increased intraocular pressure

3. Glaucoma

4. Exophthalmos

Metabolic

1. Negative nitrogen balance due to protein catabolism

The following additional adverse reactions are related to parenteral corticosteroid therapy:

1. Hyperpigmentation or hypopigmentation

2. Subcutaneous and cutaneous atrophy

3. Sterile abscess

4. Anaphylactic reaction with or without circulatory collapse, cardiac arrest, bronchospasm

5. Urticaria

6. Nausea and vomiting

7. Cardiac arrhythmias, hypotension or hypertension

A-Methapred Injection

Fluid and Electrolyte Disturbances

Sodium retention, Fluid retention, Congestive heart failure in susceptible patients, Potassium loss, Hypokalemic alkalosis, Hypertension

Musculoskeletal

Muscle weakness, Steroid myopathy, Loss of muscle mass, Severe arthralgia, Vertebral compression fractures, Aseptic necrosis of femoral and humeral heads, Pathologic fracture of long bones, Osteoporosis

Gastrointestinal

Peptic ulcer with possible perforation and hemorrhage, Pancreatitis, Abdominal distention, and Ulcerative esophagitis

Dermatologic

Impaired wound healing, Thin fragile skin, Petechiae and ecchymoses, Facial erythema, Increased sweating, May suppress reactions to skin tests

Neurological

Increased intracranial pressure with papilledema (pseudo-tumor cerebri) usually after treatment, Convulsions, Vertigo, Headache

Endocrine

Development of Cushingoid state, Suppression of growth in children, Secondary adrenocortical and pituitary unresponsiveness, particularly in times of stress, as in trauma, surgery or illness, Menstrual irregularities, Decreased carbohydrate tolerance, Manifestations of latent diabetes mellitus, Increased requirements for insulin or oral hypoglycemic agents in diabetics

Ophthalmic

Posterior subcapsular cataracts, Increased intraocular pressure, Glaucoma, Exophthalmos

Metabolic

Negative nitrogen balance due to protein catabolism

The following additional adverse reactions are related to parenteral corticosteroid therapy: Hyperpigmentation or hypopigmentation, Subcutaneous and cutaneous atrophy, Sterile abscess, Anaphylactic reaction with or without circulatory collapse, cardiac arrest, bronchospasm, Urticaria, Nausea and vomiting, Cardiac arrhythmias; hypotension or hypertension

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.